How to set up Notepad++
  1. Get the Notepad++ text editor for Windows.
  2. Get the Python programming language.
  3. Get the PythonScript for Notepad++ plug-in.

PythonScripts can go either here: <Notepad++ program folder>\plugins\PythonScript\scripts (for machine-level scripts) or here %APPDATA%\Notepad++\plugins\config\PythonScript\scripts (for user-level scripts).

You can add there also a customizable start-up script, to be run after the original one; just save it as startup.py.

And change the initialisation type from LAZY to ATSTARTUP (Notepad++: Plugins -> PythonScript -> Configuration).